Effects of prolonged bedrest in antiorthostatic position on rCBF measured by /sup 133/Xe inhalation technique - effects of clonidine
Conference
·
· Physiologist, Supplement; (United States)
OSTI ID:6942346
Experiments involving prolonged bedrest in antiorthostatic position were performed in order to simulate cardiovascular changes observed in weightlessness. Six young healthy subjects were placed in strict bedrest in a -4-deg antiorthostatic position for seven days. The rCBF (regional cerebral blood flow) measurements were made by an Xe-133 inhalation method. Three of the subjects received 0.450 mg of clonidine during the experiment. A constant increase in rCBF was observed during the first 12 hours in subjects who did not receive clonidine at the 72nd hour, all values returned to the basal state. These findings agree with the rapid correction of hemodynamic disturbances observed in the first days of weightlessness. In subjects treated with clonidine, the increase in rCBF did not occur.
- Research Organization:
- Centre Hospitalier Universitaire Rangueil, Toulouse, France
- OSTI ID:
- 6942346
- Report Number(s):
- CONF-8109186-
- Conference Information:
- Journal Name: Physiologist, Supplement; (United States) Journal Volume: 24
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ORGANS
ORIENTATION
PRIMATES
RADIOISOTOPES
RESPIRATION
TRACER TECHNIQUES
VERTEBRATES
XENON 133
XENON ISOTOPES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ORGANS
ORIENTATION
PRIMATES
RADIOISOTOPES
RESPIRATION
TRACER TECHNIQUES
VERTEBRATES
XENON 133
XENON ISOTOPES