Xe-133 rCBF measurement reproducibility and normal limits of asymmetry

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6700909

Silverstein, E B; Carney, W; Means, E D; Rauf, G C; Madden, V; Noll, R

New software for determination of regional cerebral blood flow (rCBF) has been added to equipment using Xe-133 inhalation and 32 p-m tubes in a helmet-like configuration (NOVO Cerebrograph 32c). The authors examined the reproducibility of rCBF measurements and the degree of asymmetry acceptable as normal. The 2 parameters studied were initial slope index (ISI) and CBF15, both heavily weighted toward the fast clearing compartment (largely grey matter) and relatively free of slow compartment (blurring). In 3 normal volunteers and 7 patients with non-focal stable neurologic disease ISI and CBF15 repeated within 24 hours could vary by as much as 18% and 29-33% respectively (2 s.d. limits) in stable individuals with no focal disease. In 7 patients with documented stable cerebrovascular disease, reproducibility for ISI was 19-22%, CBF15 22-23%, independent of age.

• Research Organization: Veterans Administration Medical Center, Cincinnati, OH
• OSTI ID: 6700909
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ASYMMETRY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTER CODES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EVEN-ODD NUCLEI
IMAGES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
TRACER TECHNIQUES
USES
VASCULAR DISEASES
XENON 133
XENON ISOTOPES