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Age-matched normal values and topographic maps for regional cerebral blood flow measurements by Xe-133 inhalation

Journal Article · · Stroke; (United States)
; ; ; ; ;
The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed significant negative correlation with advancing age (r . 0.70, p less than 0.001), and the regression line and its 95% confidence interval was Y . -0.32 (X - 19) + 63.5 +/- 11.2 (19 less than or equal to X less than or equal to 80). Regional ISI values also showed significant negative correlations for the entire brain (p less than 0.001). The regional reductions of ISI values with advancing age were significantly greater in the regional distribution of the middle cerebral arteries bilaterally, compared with regions in the distribution of the other arteries (p less than 0.05). Therefore, measured rCBF values for patients must be compared to age-matched normal values for mean hemispheric and each region examined. Two kinds of topographic maps, brain map showing rCBF compared to age-matched normal values and showing hemispheric differences were made by dividing patient's values by the 95% confidence limits for age-matched normal values and displaying laterality index calculated as follows, respectively. (formula; see text) These maps were useful for evaluating significantly decreased or increased regions and regional hemispheric differences.
Research Organization:
Department of Nuclear Medicine, School of Medicine, Kanazawa University, Japan
OSTI ID:
6848555
Journal Information:
Stroke; (United States), Journal Name: Stroke; (United States) Vol. 15:2; ISSN SJCCA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIFE SPAN
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
VERTEBRATES
XENON 133
XENON ISOTOPES