Metabolic fate of (U-/sup 14/C)pentachlorophenol in a lactating dairy cow

Journal Article · · J. Agric. Food Chem.; (United States)

OSTI ID:6942206

Kinzell, J H; McKenzie, R M; Olson, B A; Kirsch, D G; Shull, L R

A lactating Holstein-Friesen dairy cow was administered a single oral dose of (U-/sup 14/C)pentachlorophenol (PCP). To better simulate chronic exposure conditions on a typical dairy farm, the cow was fed 0.2 mg/kg body wt/day technical PCP for 95 days prior to (U-/sup 14/C)PCP administration and for the 4 days postadministration. Both absorption and elimination of PCP obeyed first-order kinetics and had half-lives of 4.3 and 43 h, respectively. Over the 76-h postadministration, 75% of the radiolabel was eliminated in urine, 5% in milk, and 5% in feces. The radiolabel was distributed widely into various tissues, but the highest levels were in liver, kidneys, and lungs. Skeletal muscle and adipose tissue contained among the lowest levels. In milk, the fat fraction contained the greatest amount of the radiolabel but the whey fraction represented the largest pool (62.2%). In whey and casein, both conjugated and unconjugated forms were quantified. There was no evidence of phase 1 metabolism of PCP, whereas phase 2 metabolism (conjugation) was highly evident. In urine, two-thirds of the PCP was present in a conjugated form, whereas in serum about 80% was present as unconjugated PCP. These data suggest that efficient conjugation and elimination of PCP prevent its accumulation in cattle tissues.

• Research Organization: Bio-Labs, Inc., Las Cruces, NM
• OSTI ID: 6942206
• Journal Information: J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 33:5; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CATTLE
CHLORINATED AROMATIC HYDROCARBONS
CHRONIC EXPOSURE
CONNECTIVE TISSUE
COWS
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
FOOD
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
MILK
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RUMINANTS
SIMULATION
SKELETON
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES