Cadmium metabolism and toxicity in rats after long-term subcutaneous administration
Male Sprague-Dawley rats were given sc injections of Cd at 0.5 mg/kg body weight, 6 d/wk, for 22 wk. Concentrations in the liver, kidney, spleen, heart, testis, and blood were determined every week for 8 wk and at the end of 10, 12, 15, and 22 wk. Daily excretion of Cd and total protein in urine were determined every week in another series of rats given the same dose for up to 25 wk. From these findings the response of the exposed animals could be divided into three stages. The first stage was characterized by a steady increase in hepatic and renal Cd and low-level excretion in the urine. This stage was regarded as a latent period of Cd poisoning. The second stage, which developed between 5 and 7 wk, was characterized by levelling off of Cd accumulation in the kidney and increased excretion of Cd and total protein in the urine. This was an initial toxic stage represented by renal lesions. The third stage was characterized by the second sharp increase in urinary Cd excretion and an elevated level of blood Cd after 10 wk. These responses were related to a decrease in the hepatic capacity for Cd retention as a result of toxic effects of Cd on the liver.
- Research Organization:
- National Inst. of Industrial Health, Kawasaki, Japan
- OSTI ID:
- 6941444
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 6:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
METABOLISM
TOXICITY
BIOLOGICAL EFFECTS
BLOOD
DOSE RATES
KIDNEYS
LIVER
PROTEINS
RATS
SPLEEN
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
MAMMALS
MATERIALS
METALS
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)