Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam
Journal Article
·
· Science (Washington, D.C.); (United States)
Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicate prominent accumulation of aluminum within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.
- Research Organization:
- Department of Pathology, University of Vermont College of Medicine, Burlington
- OSTI ID:
- 6940768
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 217:4564; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901 -- Pathology-- Tracer Techniques
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
ANIMAL CELLS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMICAL COMPOSITION
DISEASES
ELEMENTS
EPIDEMIOLOGY
GUAM
HIPPOCAMPUS
HUMAN POPULATIONS
ISLANDS
MARIANA ISLANDS
METALS
NERVE CELLS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NORTH AMERICA
ORGANS
PATHOLOGY
POPULATIONS
SOMATIC CELLS
TRUST TERRITORY OF THE PACIFIC ISLANDS
USA
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
ANIMAL CELLS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMICAL COMPOSITION
DISEASES
ELEMENTS
EPIDEMIOLOGY
GUAM
HIPPOCAMPUS
HUMAN POPULATIONS
ISLANDS
MARIANA ISLANDS
METALS
NERVE CELLS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NORTH AMERICA
ORGANS
PATHOLOGY
POPULATIONS
SOMATIC CELLS
TRUST TERRITORY OF THE PACIFIC ISLANDS
USA