Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25

Journal Article · Sat Jan 01 04:00:00 EST 1994 · Somatic Cell and Molecular Genetics; (United States)

DOI:https://doi.org/10.1007/BF02257489· OSTI ID:6940617

Chang, C C.Y.; Chang, W; Chang, T Y ^[1]; Noll, W W; Nutile-McMenemy, N ^[2]; Lindsay, E A; Baldini, A ^[3]

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1. Dartmouth Medical School, Hanover, NH (United States)
2. Dartmouth-Hitchcock Medical Center, Lebanon, NH (United States)
3. Institute for Molecular Genetics and Human Genome Center, Houston, TX (United States)

Acyl coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. It is believed that ACAT plays a key role in lipoprotein metabolism and atherogenesis. Recently the authors' laboratory succeeded in molecular cloning and functional expression of human macrophage ACAT cDNA. They have now mapped the ACAT gene to chromosome 1, band q25 by using fluorescence in situ hybridization to metaphase chromosomes, and by Southern blotting analysis of human-hamster somatic cell hybrid panels.

• OSTI ID: 6940617
• Journal Information: Somatic Cell and Molecular Genetics; (United States), Journal Name: Somatic Cell and Molecular Genetics; (United States) Vol. 20:1; ISSN 0740-7750; ISSN SCMGDN
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOTECHNOLOGY
CARBON-GROUP TRANSFERASES
CHROMOSOMES
DNA HYBRIDIZATION
ENZYMES
GENES
GENETIC ENGINEERING
GENETIC MAPPING
HUMAN CHROMOSOME 1
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
PROTEINS
TRANSFERASES