Quantitative comparison of the regional distributions of inhaled Tc-99m DTPA aerosol and Kr-81m Gas in coal miners' lungs

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6940353

Susskind, H; Brill, A B; Harold, W H

The authors compared the regional distribution of deposited Tc-99m DTPA aerosol (D) with that of Kr-81m (K) in the upright lungs of 22 coal miners with non-embolic pulmonary disease. Pixel-by-pixel distribution of K and D, as well as K/D ratios, were determined by computer analysis in each lung and presented as digitized posterior images. The lungs were also divided into 6.5-mm horizontal slices between apex and base. Values of the mean K and D counts and K/D ratio were plotted as functions of slice position. Good peripheral lung penetration was obtained for all subjects, while hot spots in the central airways were found in only one lung of a subject who smoked and had airway obstruction. Assessment of ventilation by visual evaluation of the respective images was comparable for both K and D. However, computer analysis showed that D was preferentially deposited in the basal regions of 38/44 lungs. K was preferentially distributed in the apical regions of 28/44 lungs. Increased bilateral D deposition in the basal regions was accompanied by a reduction in the apical regions of 10 subjects and in one lung of another 7 subjects. No relationship was found between aerosol deposition and ventilation/perfusion or pulmonary function measurements. In previous studies they have reported rapid aerosol clearance in coal miners. Although accurate clinical information has been obtained with D in patients with suspected pulmonary embolism, the effect of gravity on the deposition of D may limit its usefulness when quantitative information is required to evaluate subtle changes in ventilation in non-embolic pulmonary patients and for basic studies of ventilation and perfusion.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 6940353
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
AEROSOL MONITORING
AEROSOLS
AIR POLLUTION MONITORING
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARCINOMAS
CHELATING AGENTS
CLEARANCE
COAL MINERS
COLLOIDS
COMPARATIVE EVALUATIONS
COMPUTER GRAPHICS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DISPERSIONS
DISTRIBUTION
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
EVEN-ODD NUCLEI
EXCRETION
FLUIDS
GASES
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LUNG CLEARANCE
LUNGS
MINERS
MONITORING
NATIONAL ORGANIZATIONS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERSONNEL
PNEUMOCONIOSES
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIOPROTECTIVE SUBSTANCES
RESEARCH PROGRAMS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SECONDS LIVING RADIOISOTOPES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
US DOE
US ORGANIZATIONS
USES
YEARS LIVING RADIOISOTOPES