Clinical comparison of a new Tc-99m DTPA delivery system with Kr-81m

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6780611

Finn, J P; Myers, M J; Nair, K M; Lavender, J P

Satisfactory agents for ventilation imaging are not widely available. Access to Kr-81m is limited and image quality with Xe-133 is poor, so attention is being focused on radioaerosols as possible alternatives. The authors assessed the diagnostic value of a new Tc-99m DTPA aerosol delivery system. Forty patients were studied, most with suspected pulmonary embolism. The protocol involved FEV/sub 1/ measurement, six minutes aerosol inhalation immediately followed by steady-state Kr-81m imaging and, 60 minutes later, by Tc-99m MAA perfusion imaging. The efficiency of the system was 2%. Twenty-one patients had no central airways deposition of aerosol, 14 had 'spotty' images which were correctly interpretable and five had airways deposition sufficient to be misleading. The overall sensitivity of the test relative to Kr-81m was 75% and the specificity 84% (100% and 94% respectively among non-smokers). Airways deposition was significantly more frequent in smokers than in non-smokers and in patients whose FEV/sub 1/ was less than 50% predicted. The authors conclude that the system provides accurate clinical information in non-smokers but is of less value in smokers. It should prove a practical alternative to Xe-133.

• Research Organization: Departments of Diagnostic Radiology and Medical Physics, Hammersmith Hospital, London
• OSTI ID: 6780611
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COLLOIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISPERSIONS
DRUGS
DTPA
EFFICIENCY
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
IMAGES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLING
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROCESSING
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SECONDS LIVING RADIOISOTOPES
SENSITIVITY ANALYSIS
SMOKES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOBACCO SMOKES
USES
VENTILATION
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES