Impact of a 12-month exposure to a diurnal pattern of ozone on pulmonary function, antioxidant biochemistry and immunology

Technical Report · Sun May 01 04:00:00 EDT 1988

OSTI ID:6939682

Grose, E C; Stevens, M A; Hatch, G E; Jaskot, R H; Selgrade, M J.K.

Rats were exposed for 12 months, 13 hr/day, 7 days/week to 0.06 ppm O/sub 3/; Monday through Friday, the animals received a 9-hr spike reaching a maximum concentration of 0.25 ppm. An increase in the rate of lung nitrogen washout was observed in the O/sub 3/-exposed rats. Residual volume and total lung capacity were reduced. Glutathione peroxidase and reductase activities were increased but pulmonary superoxide dismutase was unchanged. Alpha tocopherol levels were decreased in lung lavage supernatant and unchanged in lavaged cells, however, ascorbic acid and lavage fluid protein was increased. Immunological changes were not observed. Thus, chronic exposure to O/sub 3/ caused (1) functional lung changes indicative of a stiffer lung; (2) biochemical changes suggestive of increased antioxidant metabolism; and (3) no observable immunological changes.

• Research Organization: Northrop Services, Inc., Research Triangle Park, NC (USA)
• OSTI ID: 6939682
• Report Number(s): PB-88-213160/XAB
• Country of Publication: United States
• Language: English

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