Metabolic fate of cinmethylin in goat
- E.I. du Pont de Nemours Company, Inc., Wilmington, DE (USA)
The metabolic fate of (phenyl-{sup 14}C)cinmethylin (1), a novel cineole herbicide, in a lactating goat was examined. The test animal was administered four consecutive daily doses equivalent to approximately 100 ppm cinmethylin in the daily diet. The animal was sacrificed 6 h after the last dosing. A rapid and extensive metabolism of cinmethylin was observed. The major route of elimination was via urine: 40% of the administered dose and feces (20%). ({sup 14}C)Carbon dioxide or radioactive material in the respired air and residual radioactivity in the digestive tract were not monitored. A complex degradation pattern in the excreta and liver tissue was observed. In addition to the undegraded cinmethylin, recovered only in the feces, at least 25 metabolites were isolated and identified as both organic-extractable and conjugated products. They were classified as mono-, di-, trihydroxylated, dehydrated, carboxylated, methoxylated, and ether linkage cleavage products. The level of {sup 14}C residues in the milk and tissues was low and combined to account for less than 1% of the administered radioactivity.
- OSTI ID:
- 6937599
- Journal Information:
- Journal of Agricultural and Food Chemistry; (USA), Vol. 37:3; ISSN 0021-8561
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HERBICIDES
METABOLISM
CARBON 14 COMPOUNDS
DIET
EXCRETION
FECES
GOATS
METABOLITES
ORAL ADMINISTRATION
TRACER TECHNIQUES
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DOMESTIC ANIMALS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
PESTICIDES
RUMINANTS
VERTEBRATES
WASTES
553005* - Agriculture & Food Technology- Animal Husbandry- (1987-)