Fate of (/sup 14/C)xanthotoxin (8-methoxypsoralen) in a goat and in bovine ruminal fluid

Journal Article · Tue Apr 01 00:00:00 EST 1986 · Am. J. Vet. Res.; (United States)

OSTI ID:5742345

Ivie, G W; Beier, R C; Bull, D L; Oertli, E H

A lactating Nubian goat was treated with (/sup 14/C)xanthotoxin, a photosensitizing psoralen that occurs naturally in some phototoxic range plants, as a single oral dose equivalent to 10.0 mg of xanthotoxin/kg of body weight. The radiochemical was rapidly absorbed, metabolized, and excreted. Although expired air was not monitored for the presence of volatile radiocarbon, the data indicated that greater than 50% of the administered (/sup 14/C)xanthotoxin was metabolized by cleavage of the O-(/sup 14/C)methyl moiety, with subsequent loss of the label as, presumably, (/sup 14/C)CO/sub 2/. Studies with bovine ruminal fluid in vitro indicated that cleavage of the O-methyl moiety of xanthotoxin could occur rapidly in the rumen. In the goat, nonmetabolized xanthotoxin was not excreted in urine, and of several metabolites in urine extracts, 3 were identified as resulting from opening of the furan or lactone ring. Only about 2% of the dose was recovered in the feces, and this consisted mainly of unmetabolized xanthotoxin. Although appreciable amounts of radiocarbon were secreted into milk, this radiocarbon was not in the form of xanthotoxin or any identifiable metabolites. The radiocarbon in milk likely resulted from the biosynthetic incorporation of (/sup 14/C)CO/sub 2/ into normal milk components.

• Research Organization: Agricultural Research Service, College Station, TX
• OSTI ID: 5742345
• Journal Information: Am. J. Vet. Res.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PSORALEN
EXCRETION
METABOLISM
BIOCHEMICAL REACTION KINETICS
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBON DIOXIDE
CATTLE
CLEAVAGE
FECES
GOATS
LACTATION
METABOLITES
MILK
TRACER TECHNIQUES
URINE
ANIMALS
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
COUMARINS
CRYSTAL STRUCTURE
DOMESTIC ANIMALS
DRUGS
FOOD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MICROSTRUCTURE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
REACTION KINETICS
RUMINANTS
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques