Chronic effects of vasopressin on fluid volume distribution in conscious dogs

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6937104

Merrill, D C; Cowley, Jr, A W; Skelton, M M

Previous studies have suggested that acute elevations of vasopressin (AVP) may result in an extravascular to intravascular shift of fluid independent of any change in total body H/sub 2/O (TBW). The present studies examined the chronic influence of elevated AVP on fluid volume distribution in splenectomized, sodium-deprived conscious dogs (18.9 +/- 0.7 kg) (n=5). During 4 days of continuous i.v. AVP infusion (0.36 ng/kg/min) the computerized average 24-hr total body weight was maintained within 110 gm of the control value by means of a sensitive servocontrolled scale device. Urine flow and urine osmolality averaged 335 +/- 52 ml/day and 637 +/- 36 mOsm/kg during the preinfusion period and changed to levels averaging 151 +/- 14 and 1377 +/- 121 with elevated AVP (p < .05). Red cell volume (Cr/sup 51/RBC), plasma volume, TBW (H/sub 2/O), calculated total blood volume (using Cr/sup 51/RBC and Hct) and mean arterial pressure averaged 22 +/- 1 ml/kg, 54 +/- 7 ml/kg, 0.62 +/- 0.04 L/kg, 68 +/- 3 ml/kg and 99 +/- 3 mmHg respectively during the control period and remained unchanged during the AVP infusion period. Plasma protein, Na and osmolality averaged 6.4 +/- 0.1 g/dl, 145.7 +/- 0.8 mEq/L, and 295.0 +/- 1.5 mOsm/kg during the pre-infusion period and also remained unchanged with elevated AVP. They conclude from the present studies that AVP has minimal or no chronic influence on internal volume redistribution.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 6937104
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CHRONIC EXPOSURE
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RADIOISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VASOPRESSIN
VERTEBRATES
WASTES