Cronic effects of vasopressin on fluid volume distribution in conscious dogs

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:6351789

Merrill, D C; Cowley, Jr, A W

Previous studies have suggested that acute elevations of arginine vasopressin (AVP) may result in an extravascular to intravascular shift of fluid independent of any change in total body H/sub 2/O (TBW). The present studies examined the chronic influence of elevated AVP on fluid volume distribution in five splenectomized, sodium-deprived conscious dogs. During 4 days of continuous intravenous AVP infusion the computerized average 24-h total body weight was maintained within 110 g of the control value by means of a sensitive servo-controlled scale device. Urine flow and urine osmolality averaged 335 +/- 52 ml/day and 637 +/- 36 mosmol/kg during the preinfusion period and changed to levels averaging 151 +/- 14 and 1377 +/- 121 with elevated AVP. Chromium-51-labeled red cell volume (/sup 51/Cr RBC), plasma volume (Evans blue), TBW (/sup 3/H/sub 2/O), calculated total blood volume (using /sup 51/Cr RBC and Hct), and mean arterial pressure remained unchanged during the AVP infusion period. Plasma protein, sodium, and osmolality also remained unchanged with elevated AVP. The authors conclude from the present studies that AVP has minimal or chronic influence on internal volume redistribution.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 6351789
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:1; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BLOOD PLASMA
BODY FLUIDS
CHALCOGENIDES
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HORMONES
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
OXIDES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PHYSIOLOGY
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRITIUM OXIDES
URINE
VASOPRESSIN
VERTEBRATES
VOLUME
WASTES