Inhalation developmental toxicology studies: Teratology study of n-hexane in mice: Final report

Technical Report · Sun May 01 04:00:00 EDT 1988

DOI:https://doi.org/10.2172/6936329· OSTI ID:6936329

Mast, T J; Decker, J R; Stoney, K H; Westerberg, R B; Evanoff, J J; Rommereim, R L; Weigel, R J

Gestational exposure to n-hexane resulted in an increase in the number of resorbed fetuses for exposure groups relative to the control group; however, the increases were not directly correlated to exposure concentration. The differences were statistically significant for the 200-ppM with respect to total intrauterine death (early plus late resorptions), and with respect to late resorptions for the 5000-ppM group. A small, but statistically significant, reduction in female (but not male) fetal body weight relative to the control group was observed at the 5000-ppM exposure level. There were no exposure-related increases in any individual fetal malformation or variation, nor was there any increase in the incidence of combined malformations or variations. Gestational exposure of CD-1 mice to n-hexane vapors appeared to cause a degree of concentration-related developmental toxicity in the absence of overt maternal toxicity, but the test material was not found to be teratogenic. This developmental toxicity was manifested as an increase in the number of resorptions per litter for all exposure levels, and as a decrease in the uterine: extra-gestational weight gain ratio at the 5000-ppM exposure level. Because of the significant increase in the number of resorptions at the 200-ppM exposure level, a no observable effect level (NOEL) for developmental toxicity was not established for exposure of mice to 200, 1000 or 5000-ppM n-hexane vapors. 21 refs., 3 figs., 9 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6936329
• Report Number(s): PNL-6590; ON: DE88012680
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
CONGENITAL MALFORMATIONS
DOCUMENT TYPES
FETUSES
HEXANE
HYDROCARBONS
INHALATION
INTAKE
MALFORMATIONS
MAMMALS
MATTER
MICE
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRENATAL EXPOSURE
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VOLATILE MATTER