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Sister chromatid exchange in painters recently exposed to solvents

Journal Article · · Environmental Research; (USA)
; ;  [1];  [2];  [3]
  1. Harvard School of Public Health, Boston, MA (USA)
  2. National Institute for Occupational Safety and Health, Atlanta, GA (USA)
  3. Univ. of California, San Francisco (USA)
+ Show Author Affiliations
Epidemiologic studies have suggested that exposure to solvent-based materials in the painting trades is associated with an increased cancer risk. In order to determine if the solvent exposures of current union members of the International Brotherhood of Painters and Allied Tradesman (IBPAT) are associated with a genotoxic risk, we have measured the sister chromatid exchanged (SCE) frequency in their peripheral blood lymphocytes. Previous reports have shown that chronic solvent exposure of these workers dose not elevated SCE frequencies. We now report that acute exposure, estimated by number of days worked over the month prior to venipuncture, is associated with elevated SCE levels in currently smoking workers. No elevation in SCE was associated with similar recent exposure in nonsmoking, solvent-exposed painters.
OSTI ID:
6936175
Journal Information:
Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 50:2; ISSN ENVRA; ISSN 0013-9351
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
COATINGS
COLLOIDS
CONNECTIVE TISSUE CELLS
CORRELATIONS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATION FREQUENCY
MUTATIONS
NEOPLASMS
OCCUPATIONAL EXPOSURE
PAINTS
PATHOGENESIS
RESIDUES
RISK ASSESSMENT
SISTER CHROMATID EXCHANGES
SMOKES
SOLS
SOLVENTS
SOMATIC CELLS
TOBACCO SMOKES