Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Environ. Mol. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850110310· OSTI ID:6922005

Kelsey, K T; Wiencke, J K; Little, F F; Baker, Jr, E L; Little, J B

A cross-sectional study of sister chromatid exchange frequency (SCE) in peripheral blood lymphocytes from 117 members of the International Brotherhood of Painters and Allied Tradesman was conducted in union locals in two major US cities. Chronic solvent exposure intensity and duration were estimated from interviewer-administered-questionnaire data. SCE for all of the workers in the study were scored by one reader. A second reader determined the SCE frequency from a random sample of 30 workers. Age, coffee and alcohol intake and chronic solvent exposure (both intensity and duration, estimated over the working lifetime and over the year prior to study for each worker) did not significantly elevate SCE. The effect of smoking on SCE frequency, assessed by analysis of variance controlling for other possible confounding factors, showed that smoking increased SCE frequency. The SCE frequency in the smoking, solvent-exposed (estimated as lifetime exposure) painters were 6.75 SCE/cell; in the non-smoking, solvent-exposed workers the SCE frequency was 5.73 SCE/cell. These observations are consistent with other work suggesting that chronic solvent exposure in the paint trade is not associated with an elevation in SCE in peripheral blood lymphocytes. However, further work is necessary to address adequately the question of the genotoxicity of acute solvent exposure in these workers.

• Research Organization: Harvard School of Public Health, Boston, MA (USA)
• OSTI ID: 6922005
• Journal Information: Environ. Mol. Mutagen.; (United States), Journal Name: Environ. Mol. Mutagen.; (United States) Vol. 11:3; ISSN ENMUE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CHRONIC EXPOSURE
COATINGS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATION FREQUENCY
MUTATIONS
PAINTS
PERSONNEL
RESIDUES
SISTER CHROMATID EXCHANGES
SMOKES
SOLS
SOLVENTS
SOMATIC CELLS
TOBACCO SMOKES