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Title: Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development (42361)

Abstract

Diets specifically deficient in selenium (Se) and/or vitamin E or adequate in both nutrients were fed to chicks from the time of hatching. Lymphoid organs (bursa, thymus, and in some instances, spleen) were collected from chicks 7-35 days of age. Growth of the chicks fed these diets was monitored over the experimental period as was lymphoid organ growth. The development of the primary lymphoid organs was further assessed by histological techniques and the organ contents of vitamin E (..cap alpha..-tocopherol) and Se were determined. Specific deficiencies of either Se or vitamin E were found to significantly impair bursal growth as did a combined deficiency. Thymic growth was impaired only by the combined deficiency diet. Severe histopathological changes in the bursa resulted from the combined deficiency and these were detectable by 10-14 days after hatching. These changes were characterized by a gradual degeneration of the epithelium and an accompanying depletion of lymphocytes. Similar changes, although slower to develop and less severe, were observed in the thymus as a result of the combined deficiency. When both serum and tissue levels of vitamin E and Se were monitored, it was observed that these were rapidly and independently depleted by the specific deficiency diets.more » These data suggest that the primary lymphoid organs are major targets of Se and vitamin E dietary deficiencies and provide a possible mechanism by which immune function may be impaired.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Cornell Univ., Ithaca, NY
OSTI Identifier:
6936086
Alternate Identifier(s):
OSTI ID: 6936086
Resource Type:
Journal Article
Resource Relation:
Journal Name: Proc. Soc. Exp. Biol. Med.; (United States); Journal Volume: 182:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHICKENS; ANIMAL GROWTH; SELENIUM; BIOLOGICAL EFFECTS; VITAMIN E; CRITICAL ORGANS; EPITHELIUM; IMMUNOLOGY; LYMPHOCYTES; NUTRITIONAL DEFICIENCY; PATHOLOGICAL CHANGES; THYMUS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL MATERIALS; BIRDS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELEMENTS; FOWL; GROWTH; LEUKOCYTES; LYMPHATIC SYSTEM; MATERIALS; ORGANS; SEMIMETALS; SOMATIC CELLS; TISSUES; VERTEBRATES; VITAMINS 550500* -- Metabolism

Citation Formats

Marsh, J.A., Combs, G.F. Jr., Whitacre, M.E., and Dietert, R.R. Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development (42361). United States: N. p., 1986. Web. doi:10.3181/00379727-182-42361.
Marsh, J.A., Combs, G.F. Jr., Whitacre, M.E., & Dietert, R.R. Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development (42361). United States. doi:10.3181/00379727-182-42361.
Marsh, J.A., Combs, G.F. Jr., Whitacre, M.E., and Dietert, R.R. Mon . "Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development (42361)". United States. doi:10.3181/00379727-182-42361.
@article{osti_6936086,
title = {Effect of selenium and vitamin E dietary deficiencies on chick lymphoid organ development (42361)},
author = {Marsh, J.A. and Combs, G.F. Jr. and Whitacre, M.E. and Dietert, R.R.},
abstractNote = {Diets specifically deficient in selenium (Se) and/or vitamin E or adequate in both nutrients were fed to chicks from the time of hatching. Lymphoid organs (bursa, thymus, and in some instances, spleen) were collected from chicks 7-35 days of age. Growth of the chicks fed these diets was monitored over the experimental period as was lymphoid organ growth. The development of the primary lymphoid organs was further assessed by histological techniques and the organ contents of vitamin E (..cap alpha..-tocopherol) and Se were determined. Specific deficiencies of either Se or vitamin E were found to significantly impair bursal growth as did a combined deficiency. Thymic growth was impaired only by the combined deficiency diet. Severe histopathological changes in the bursa resulted from the combined deficiency and these were detectable by 10-14 days after hatching. These changes were characterized by a gradual degeneration of the epithelium and an accompanying depletion of lymphocytes. Similar changes, although slower to develop and less severe, were observed in the thymus as a result of the combined deficiency. When both serum and tissue levels of vitamin E and Se were monitored, it was observed that these were rapidly and independently depleted by the specific deficiency diets. These data suggest that the primary lymphoid organs are major targets of Se and vitamin E dietary deficiencies and provide a possible mechanism by which immune function may be impaired.},
doi = {10.3181/00379727-182-42361},
journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 182:4,
place = {United States},
year = {Mon Sep 01 00:00:00 EDT 1986},
month = {Mon Sep 01 00:00:00 EDT 1986}
}