Comparative inhalation toxicology of selected materials. Final report on Phase 1

Technical Report · Mon Sep 01 00:00:00 EDT 1986

OSTI ID:6935197

Snipes, M B; Burt, D G; Eidson, A F; Hahn, F F; Harmsen, A G

Studies are being conducted with Fischer-344 rats to determine the inhalation toxicology of a respirable power of copper-zinc alloy. Phase I involved standardization of methods, characterization of aerosols, and exposures of rats in whole-body of nose-only systems to air concentrations of 100 mg Cu-Zn/m/sup 3/, or 100 mg titanium dioxide/m/sup 3/. The titanium dioxide was included to determine if effects observed in exposed animals resulted from inhaling the Cu-Zn powder or inhaling a comparable amount of nuisance dust. Sham-exposed and shelf control rats were included. Rats were exposed 2.5 hr/day for 2 or 5 consecutive days, then killed for evaluations. Results include body weights, core temperatures, selected organ weights, hematology, clinical chemistry, and histopathology. Significant findings were 1) all rats were stressed when exposed in whole-body or nose-only exposure systems, 2) except for a greater body weight loss for rats exposed nose-only, indicators of stress were similar for the two types of exposure systems, 3) no consistent differences were seen between sham-exposed and TiO/sub 2/-exposed rats, and 4)adverse effects from exposure to Cu-Zn alloy powder included body weight loss, decreased ability to maintain body temperature (measured in rats exposed nose-only), rhinitis, and an inflammatory response in the lung.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA). Inhalation Toxicology Research Inst.
• OSTI ID: 6935197
• Report Number(s): AD-A-176250/9/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
INHALATION
TOXICITY
COPPER ALLOYS
TITANIUM OXIDES
ZINC ALLOYS
BODY TEMPERATURE
CHEMISTRY
CONTROL
HEMATOLOGY
INDICATORS
RATS
RESPIRATION
STRESSES
WEIGHT
ALLOYS
ANIMALS
CHALCOGENIDES
COLLOIDS
DISPERSIONS
INTAKE
MAMMALS
MEDICINE
OXIDES
OXYGEN COMPOUNDS
RODENTS
SOLS
TITANIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology