Comparative inhalation toxicology of selected materials. Phase 2. Final report, January-July 1986

Technical Report · Sun May 01 00:00:00 EDT 1988

OSTI ID:6598403

Snipes, M B; Bice, D E; Burt, D G; Damon, E G; Eidson, A F

Male and female F344/N rats were exposed nose-only to a respirable powder of copper-zinc alloy. No rats died as a result of the exposures. Body weights were reduced relative to sham-exposed rats for rats exposed to 240 and 480 mg. hr Cu-Zn/cu.m week. All of the additional observed biological responses to inhaled Cu-Zn were restricted to the respiratory tract. Lung weights were increased due to an inflammatory response for rats exposed to 120 mg. hr Cu-Zn/cu.m or more per week. Exposure to 240 mg. hr Cu-zn/cu.m per week caused restrictive pulmonary functional disorder, as evidenced by a reduced lung capacity, reduced quasi-static compliance, reduced carbon monoxide diffusing capacity, and increased percent forced vital capacity exhaled in 0.1 second. Exposure-related responses in lavage-fluid indicators of lung damage included increased beta-glucuronidase, increased lactate dehydrogenase, and increases in inflammatory cells, total protein, and collagen. Histological lesions produced by Cu-Zn were atrophy of the nasal olfactory epithelium and hyperplasia of goblet cells in the respiratory epithelium, focal necrotizing alveolitis, alveolar macrophage hyperplasia, and goblet cell hyperplasia of bronchial and bronchiolar epithelium. The inhaled Cu-Zn alloy caused exposure-related inflammatory and cytotoxic responses in the respiratory tract, but the inhaled Cu-Zn cleared rapidly and the responses largely resolved after cessation of exposures.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA). Inhalation Toxicology Research Inst.
• OSTI ID: 6598403
• Report Number(s): AD-A-199196/7/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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TOXIC MATERIALS
COMPARATIVE EVALUATIONS
AIR POLLUTION
ATROPHY
CARBON MONOXIDE
COLLAGEN
COPPER ALLOYS
DAMAGE
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ANIMAL TISSUES
ANIMALS
BODY
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DOCUMENT TYPES
INTAKE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
RODENTS
SCLEROPROTEINS
SYMPTOMS
TISSUES
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560300* - Chemicals Metabolism & Toxicology
550900 - Pathology