Pulmonary response to exposure to ozone of emphysematous rats

Journal Article · Sat Jan 31 23:00:00 EST 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80012-9· OSTI ID:6934952

Yokoyama, E; Nambu, Z; Ichikawa, I; Uchiyama, I; Arakawa, H

Rats were treated with a single intratracheal instillation of 6.5 units elastase or normal saline. Seven weeks after treatment, the animals were exposed for 24 hr to filtered air or 1 ppm O3, and their lung functions were measured. The exposure to O3 resulted in functional changes depending mainly on peripheral airway obstruction, and the direction and degree of those functional changes were in general similar between the saline- and elastase-treated animals. Another group of saline- or elastase-treated rats were exposed to 3 ppm O3 for 3 hr and the edematous response of their lungs was again similar. These results indicate that elastase-treated lungs responded to the exposure to O3 in a fashion similar to normal lungs in rats, but lung damage caused by the exposure to O3 superimposed over preexisting emphysematous damage, resulted in an additional lessening of the margin of pulmonary reserve capacity.

• Research Organization: Institute of Public Health, Tokyo, Japan
• OSTI ID: 6934952
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
DISEASES
DYNAMIC FUNCTION STUDIES
EDEMA
EMPHYSEMA
INTRATRACHEAL ADMINISTRATION
LUNGS
MAMMALS
ORGANS
OZONE
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SYMPTOMS
TOXICITY
VERTEBRATES