Altered pulmonary epithelial permeability in canine radiation lung injury
A radioaerosol scanning technique measuring regional clearance of sodium pertechnetate (99mTcO-4) and 99mTc-labeled diethylenetriaminepentaacetate (99mTc-DTPA) was used to assess changes in canine pulmonary epithelial permeability following lung irradiation. Doses of 2000 cGy (11 dogs), 1000 cGy (2 dogs), and 500 cGy (2 dogs) were given in one fraction to either the entire right hemithorax (500 cGy) or the right lower lung (1000 and 2000 cGy). Radioaerosol scans, chest roentgenograms, and computerized tomograms (CT) were obtained before and serially after irradiation. A dose of 2000 cGy resulted in a decrease in regional pulmonary epithelial permeability to both 99mTcO4- and 99mTc-DTPA; both showed significant decreases from the 2nd wk postirradiation onward. In comparison, CT and chest roentgenogram did not become abnormal until 7.1 +/- 2.8 (SD) and 8.2 +/- 2.6 wk, respectively. Doses of 1,000 and 500 cGy produced reversible decreases in 99mTcO4- clearance. Lung morphology showed definite changes of radiation pneumonitis after 2000 and 1000 cGy but not after 500 cGy at approximately 9, 17, and 12 wk postirradiation, respectively. These results suggest that dose-dependent changes in pulmonary physiology may precede obvious structural alterations in radiation lung injury.
- Research Organization:
- Univ. of Alberta, Edmonton
- OSTI ID:
- 6933946
- Journal Information:
- J. Appl. Physiol.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DTPA
LUNG CLEARANCE
EPITHELIUM
BIOLOGICAL RADIATION EFFECTS
LUNGS
PERTECHNETATES
BIOMEDICAL RADIOGRAPHY
COMPUTERIZED TOMOGRAPHY
DIFFUSION
DOGS
LABELLED COMPOUNDS
PERMEABILITY
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
TECHNETIUM 99
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
REFRACTORY METAL COMPOUNDS
RESPIRATORY SYSTEM
SOLS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TISSUES
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals