Microvascular leakage of plasma proteins after PUVA and UVA
The transcapillary escape rate of albumin (TERalb), is a parameter of the leakage of macromolecules from the total microvasculature. In patients with psoriasis short-term PUVA treatment induces an increase in TERalb. In this study TERalb was measured in 3 groups of normal humans treated with PUVA, UVA and 8-methoxypsoralen. Treatment with PUVA and UVA caused a statistically significant increase in TERalb, whereas treatment with 8-methoxypsoralen did not induce any measurable changes. It is concluded that the UVA irradiation causes the abnormal leakage of macromolecules, whereas psoralen is not the responsible component. Furthermore the phenomenon can be elicited in normals and is not based on a preexisting psoriasis.
- Research Organization:
- Departments of Clinical Physiology and Dermatology, The Finsen Institute, Copenhagen, Denmark
- OSTI ID:
- 6933711
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 78:4; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
COUMARINS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MATHEMATICS
MEASURING METHODS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATIENTS
PERMEABILITY
PROTEINS
PSORALEN
PSORIASIS
QUANTITATIVE CHEMICAL ANALYSIS
RADIATIONS
SKIN DISEASES
STATISTICS
THERAPY
ULTRAVIOLET RADIATION