Three-compartment modeling of C-11 N-Methyl spiperone kinetics in the human brain
N-Methyl spiperone, as well as spiperone, has been used to study the dopamine receptor system in the brain. The authors have applied a 3-compartment model consisting of vascular, extravascular unbound, and receptor-bound activity to two normal volunteers and one patient with Parkinson's disease. The model differs from that proposed by another study, in that, as in the Sokoloff model for deoxyglucose, there is no explicit term for blood flow. Furthermore, the authors used a 3-compartment model for the cerebellum as well as the caudate/putamen. Serial scans were obtained by PET for up to 2 hrs after injection of the tracer. Time-activity curves were generated over the caudate, putamen and cerebellum. The results indicate a close fit of the observed data to the 3-compatment model. In the model, K1 represents the rate constant of delivery of the tracer in the tissue from the vascular compartment. K2 is the reverse rate constant. K1 was approximately equal to K2 for the cerebellum. In the basal ganglia, K2 was less than K1 due to nonspecific binding in compartment 2. K3 represents the rate constant of binding of the tracer to the receptor binding sites in the cerebral cortex and basal ganglia and to nonspecific binding sites in the cerebellum which contains essentially no dopamine receptors. K4 represents the rate constant for dissociation of the tracer from the receptors. For N-methyl spiperone K4 is very low in the caudate/putamen. The 3-compartment model seemed to fit the data better than the 2-compartment model for both the caudate/putamen and cerebellar activity.
- Research Organization:
- National Institutes of Health, Bethesda, MD
- OSTI ID:
- 6929159
- Report Number(s):
- CONF-840619-; TRN: 87-008948
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
Similar Records
Kinetic analysis of 3-quinuclidinyl 4-( sup 125 I)iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: Implications for human studies
Measurement of binding potential of [C11]WIN 35,428 for dopamine re-uptake site in normal human brain: Comparison of graphical and non-linear least-squares analytic method
Related Subjects
CEREBELLUM
ANATOMY
POSITRON COMPUTED TOMOGRAPHY
CEREBRUM
DOPAMINE
RECEPTORS
BLOOD FLOW
DISSOCIATION
GLUCOSE
MATHEMATICAL MODELS
TRACER TECHNIQUES
ALDEHYDES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARBOHYDRATES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
MEMBRANE PROTEINS
MONOSACCHARIDES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
SACCHARIDES
SYMPATHOMIMETICS
TOMOGRAPHY
550801* - Morphology- Tracer Techniques
550901 - Pathology- Tracer Techniques