Quantification of platelet thrombosis on bovine pericardial valve prostheses and reduction of thrombosis with diphosphonate treatment in calves
Conference
·
· J. Nucl. Med.; (United States)
OSTI ID:6928989
Effect of calcification-inhibitor, sodium diphosphonate on thrombosis on bovine pericardial valve prostheses was evaluated in 4-week-old Holstein calves with In-111 labeled platelets. Twenty-two calves, 11 control, 11 diphosphonate treated (5 mg/kg/day, subcutaneously) were implanted with 25 mm bovine pericardial valve prostheses in mitral annulus and killed 30 and 90 days post-implantation. Twenty-four hours before killing 350-450 ..mu..Ci of autologous In -111 platelets were administered I.V. Components of valve were separated, weighed and area determined. Mean (+-SD) value of platelet deposition (platelet x 10/sup 3//mm/sup 2/) on four sections of leaflet (free edge, central zone, flexion zone, and attachment zone) was calculated from platelet count, radioactivity in blood, leaflet sections and area. In addition to reduction of calcification, diphosphonate also reduces platelet thrombosis in tissue valve prostheses. Platelet deposition at free edge increased at 90 days due to rough calcified surface in control calves.
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 6928989
- Report Number(s):
- CONF-840619-
- Conference Information:
- Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Noninvasive radioisotopic technique for detection of platelet deposition on bovine pericardial mitral-valve prosthesis and in vitro quantification of visceral microembolism in dogs
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6759979
Quantitation of platelet and fibrinogen-fibrin deposition on components of tissue valves (Ionescu-Shiley) in calves
Journal Article
·
Tue Jul 01 00:00:00 EDT 1986
· ASAIO Trans.; (United States)
·
OSTI ID:6777929
Noninvasive radioisotopic technique for detection of platelet deposition on bovine pericardial mitral-valve prosthesis and in vitro quantification of visceral microembolism in dogs
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· Trans., Am. Soc. Artif. Intern. Organs; (United States)
·
OSTI ID:7190442
Related Subjects
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATTLE
DISEASES
DOMESTIC ANIMALS
HEART
IMPLANTS
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PERICARDIUM
PHOSPHONATES
PROSTHESES
RUMINANTS
SEROUS MEMBRANES
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATTLE
DISEASES
DOMESTIC ANIMALS
HEART
IMPLANTS
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PERICARDIUM
PHOSPHONATES
PROSTHESES
RUMINANTS
SEROUS MEMBRANES
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES