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A new technique for quantification of platelet thrombosis on bovine pericardial valve prostheses (Ionescu-Shiley) in calves with indium-111 labeled platelets

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6759979
; ; ; ; ; ; ;
Platelet thrombosis on components of tissue valve prosthesis explanted from Holstein calves was quantified with In-111-labeled autologous platelets. Twenty-eight calves were implanted with 25 mm bovine pericardial valve prostheses in mitral annulus and killed 1, 14, 30 and 90 days post-implantation. Twenty-four hours before killing 350-450 ..mu..Ci of autologous In-111 platelets were administered intravenously. Components of the explanted valve were imaged with a gamma camera. Mean (+- SD) value of platelet deposition (PlX10/sup 5//mm/sup 2/) on four sections of each leaflet (free edge: FE, central zone: CZ, flexion zone: FZ, attachment zone: AZ) was calculated from platelet count, radioactivity in blood, leaflet sections and area of leaflet sections. With fibrous ingrowth in sewing ring the tissue valve becomes less thrombogenic at 30 days post-implantation; with increase in calcification platelet thrombosis also increases in central zone of leaflet at 30 and 90 days.
Research Organization:
Mayo Clinic and Foundation, Rochester, MN
OSTI ID:
6759979
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAT SCANNING
CATTLE
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
COWS
DAYS LIVING RADIOISOTOPES
DETECTION
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
GAMMA CAMERAS
GRAFT-HOST REACTION
HEART
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PERICARDIUM
PROSTHESES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUMINANTS
SCINTISCANNING
SEROUS MEMBRANES
THROMBOSIS
TOMOGRAPHY
VASCULAR DISEASES
VERTEBRATES