Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Second malignancy in patients treated for Hodgkin's disease

Journal Article · · Cancer; (United States)
 [1]; ;
  1. Univ. of Trieste, Italy
+ Show Author Affiliations
Six hundred and thirteen consecutive patients with Hodgkin's disease (HD), with a follow-up of two to ten years, were reviewed with the aim of establishing the type and frequency of second malignancies. Acute non-lymphoid leukemia developed in 2 of 152 patients treated by chemotherapy (CHT), and in 5 of 344 patients treated by CHT and radiotherapy (RT). Leukemia developed 12 to 83 months after diagnosis of HD, was always preceded by a preleukemic phase (3 to 25 months), and was always fatal (after 1 to 12 months). The karyotype of leukemic cells was studied in 4 of 7 patients and was always abnormal. Solid tumors developed in 1 of 152 patients treated by CHT, and in 4 of 344 patients treated by CHT and RT. The tumors appeared 10 to 63 months after diagnosis of HD and killed all 5 patients after 10 to 16 months. For patients treated by CHT, the actuarial frequency of leukemia and other tumors seven years after diagnosis of HD was 2.0% and 1.26%, respectively. For patients treated by CHT and RT, the figures were 2.04% and 2.26%, respectively. Second malignancies were not recorded among 117 patients treated by RT alone. These data are consistent with a relationship of acute leukemia to therapy for HD.
OSTI ID:
6926058
Journal Information:
Cancer; (United States), Journal Name: Cancer; (United States) Vol. 46:8; ISSN CANCA
Country of Publication:
United States
Language:
English

Similar Records

Second lymphoid malignant neoplasms occurring in patients treated for Hodgkin's disease
Journal Article · Mon Feb 28 23:00:00 EST 1983 · Arch. Intern. Med.; (United States) · OSTI ID:5682452
Second primary cancer following Hodgkin's disease: Updated results of an Italian multicentric study
Journal Article · Thu Feb 28 23:00:00 EST 1991 · Journal of Clinical Oncology; (USA) · OSTI ID:5952633
Second malignancies complicating Hodgkin's disease: a Southwest Oncology Group 10-year followup
Journal Article · Wed Mar 31 23:00:00 EST 1982 · Cancer Treat. Rep.; (United States) · OSTI ID:7054684

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
DISEASES
HEMIC DISEASES
HODGKINS DISEASE
LATENCY PERIOD
LEUKEMIA
LEUKEMOGENESIS
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATHOGENESIS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
THERAPY