Carcinogenicity of benzo(a)pyrene and thirteen of its derivatives in C3H/fCum mice

Journal Article · Sat Mar 01 04:00:00 EST 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6925662

Kouri, R E ^[1]; Wood, A W; Levin, W; Rude, T H; Yagi, H; Mah, H D; Jerina, D M; Conney, A H

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1. Microbiological Associates, Bethesda, MD

Benzo(a)pyrene (BP) and 13 of its derivatives were tested for their ability to induce fibrosarcomas in inbred male C3H/fCum mice after a single sc injection. A 0.9-..mu..mol dose of BP in 0.05 ml dimethyl sulfoxide or 0.1 ml trioctanoin produced a 63 or 83% tumor incidence, respectively. At the same dose, benzo(a)pyrene-7,8-oxide had very weak tumorigenic activity whereas the benzo(a)pyrene-4.5-, 9.10-,and 11.12-oxides had no tumorigenic activity. When administered in dimethyl sulfoxide, (+-0-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-dihydrodiol) had tumorigenic activity comparable to BP. However, the tumorigenicity of this dihydrodiol was lost when it was injected in trioctanion. The potent tumorigenicity of 7,8-dihydrobenzo(a)pyrene, compared to that of 9,10-dihydrobenzo(a)pyrene, provided evidence for the importance of an intact 9,10-double bond for the metabolic activation of BP. 2-Hydroxybenzo(a)pyrene, a potent carcinogen on mouse skin and in the newborn mouse, was only 10% as active as BP after sc injection in the mouse.

• OSTI ID: 6925662
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 64:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
CARCINOGENESIS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DISEASES
DMSO
FIBROSARCOMAS
HYDROCARBONS
INJECTION
INTAKE
MAMMALS
METABOLIC ACTIVATION
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
RODENTS
SARCOMAS
SUBCUTANEOUS INJECTION
SULFOXIDES
VERTEBRATES