Chemiluminescence assay specific for the microsomal metabolite, benzo(a)pyrene-7,8-dihydrodiol
Journal Article
·
· Anal. Biochem.; (United States)
The presence of trans-7,8dihydroxy7,8-dihydrobenzo(a)-pyrene (BP-7,8-dihydrodiol) in complex metabolite mixtures produced during microsomal metabolism of benzo(a)pyrene (BP) may be determined. Only the BP-7,8-dihydrodiol metabolite will produce significant chemiluminescence (CL) in the NaOCl-H/sub 2/O/sub 2/ singlet oxygen-generating system. The limiting CL sensitivity is 30 pmol in a 1-ml CL reaction mixture. CL assays for BP-7,8-dihydrodiol in microsomal reaction solutions produced results identical with those determined by calibrated high-performance liquid chromatography. 10 references, 2 figures, 1 table.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD
- OSTI ID:
- 5942691
- Journal Information:
- Anal. Biochem.; (United States), Journal Name: Anal. Biochem.; (United States) Vol. 130; ISSN ANBCA
- Country of Publication:
- United States
- Language:
- English
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Fri Dec 31 23:00:00 EST 1976
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OSTI ID:5088847
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Journal Article
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OSTI ID:6789428
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKALI METAL COMPOUNDS
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BODY
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CHEMILUMINESCENCE
CHLORINE COMPOUNDS
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DIGESTIVE SYSTEM
EPOXIDES
EXPERIMENTAL DATA
GLANDS
GLYCOLS
HALOGEN COMPOUNDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
INFORMATION
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUMINESCENCE
MAMMALS
METABOLISM
METABOLITES
MICROSOMES
MUTAGENS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYCHLORIDES
OXYGEN COMPOUNDS
PEROXIDES
QUALITATIVE CHEMICAL ANALYSIS
RATS
RODENTS
SEPARATION PROCESSES
SODIUM COMPOUNDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKALI METAL COMPOUNDS
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BODY
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CHEMILUMINESCENCE
CHLORINE COMPOUNDS
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DIGESTIVE SYSTEM
EPOXIDES
EXPERIMENTAL DATA
GLANDS
GLYCOLS
HALOGEN COMPOUNDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
INFORMATION
LIQUID COLUMN CHROMATOGRAPHY
LIVER
LUMINESCENCE
MAMMALS
METABOLISM
METABOLITES
MICROSOMES
MUTAGENS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYCHLORIDES
OXYGEN COMPOUNDS
PEROXIDES
QUALITATIVE CHEMICAL ANALYSIS
RATS
RODENTS
SEPARATION PROCESSES
SODIUM COMPOUNDS
VERTEBRATES