Metabolic effects of 3'-deoxyadenosine (cordycepin) and 2-halo-3'-deoxyadenosine on repair of X-ray-induced potentially lethal damage in Chinese hamster V79 cells
Journal Article
·
· Radiat. Res.; (United States)
Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR.
- Research Organization:
- Hokkaido Univ., Sapporo (Japan)
- OSTI ID:
- 6922833
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 114:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Effect of cordycepin(3'-deoxyadenosine) on excision repair of 5,6-dihydroxy-dihydrothymine-type products from the DNA of Micrococcus radiodurans
Journal Article
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Fri Oct 31 23:00:00 EST 1980
· Radiat. Res.; (United States)
·
OSTI ID:6701055
Inhibition of phosphorylation of cardiac troponin-I by adenosine and 5'-chloro 5'-deoxyadenosine
Conference
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5022890
Effect of cordycepin(3'-deoxyadenosine) on excision repair of 5,6-dihydroxy-dihydrothymine-type products from the DNA of Micrococcus radiodurans
Journal Article
·
Fri Jul 01 00:00:00 EDT 1983
· Radiat. Res.; (United States)
·
OSTI ID:5816056
Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOSINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
CHEMICAL REACTIONS
DNA
DNA REPAIR
ELECTROMAGNETIC RADIATION
ENZYMES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
IONIZING RADIATIONS
LUNGS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHORYLATION
PHOSPHOTRANSFERASES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
TRANSFERASES
VERTEBRATES
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOSINE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CULTURES
CHEMICAL REACTIONS
DNA
DNA REPAIR
ELECTROMAGNETIC RADIATION
ENZYMES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
IONIZING RADIATIONS
LUNGS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHORYLATION
PHOSPHOTRANSFERASES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
TRANSFERASES
VERTEBRATES
X RADIATION