Uptake of cadmium-109, a metallothionein-binding radiometal, by tumors in mice as a function of the transformed phenotype
Journal Article
·
· Invest. Radiol.; (United States)
Metallothionein (MT) is an intracellular protein that binds many metals with isotopes having imaging or radiotherapeutic potential. To determine whether uptake of radioisotopes that bind to MT is increased in tumors, we measured the uptake of cadmium-109 (Cd-109) in tumors and in normal tissues of mice. Tumors were grown in Balb/C mice from cultured Balb/3T3 cells transformed by the Moloney murine sarcoma virus (MMSV). Uptake of Cd-109 by MMSV tumors exceeded that by normal tissues examined, with the exception of liver and kidney (the organs known to be richest in metallothionein). The MMSV tumor:background ratios of activity were greater for Cd-109 than for gallium-67 for many of the normal tissues examined. The magnitude of uptake of Cd-109 by tumors from four related cell lines paralleled their degree of expression of two indices of the transformed, or malignant, phenotype. We conclude that metals that bind to MT may be useful for imaging or radiotherapy of cancer.
- Research Organization:
- Veterans Administration Medical Center, Salt Lake City, UT (USA)
- OSTI ID:
- 6922418
- Journal Information:
- Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 23:3; ISSN INVRA
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5244205
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·
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Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CADMIUM 109
CADMIUM ISOTOPES
CELL TRANSFORMATIONS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
MICE
NEOPLASMS
NUCLEI
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHENOTYPE
PROTEINS
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
RODENTS
TISSUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CADMIUM 109
CADMIUM ISOTOPES
CELL TRANSFORMATIONS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
MICE
NEOPLASMS
NUCLEI
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHENOTYPE
PROTEINS
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
RODENTS
TISSUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES