Effects of carbon dioxide on Penicillium chrysogenum: an autoradiographic study

Journal Article · Mon Jun 20 04:00:00 EDT 1988 · Biotechnol. Bioeng.; (United States)

DOI:https://doi.org/10.1002/bit.260320103· OSTI ID:6922279

Edwards, A G; Ho, C S

Previous research has shown that dissolved carbon dioxide causes significant changes in submerged penicillin fermentations, such as stunted, swollen hyphae, increased branching, lower growth rates, and lower penicillin productivity. Influent carbon dioxide levels of 5 and 10% were shown through the use of autoradiography to cause an increase in chitin synthesis in submerged cultures of Penicillium chrysogenum. At an influent 5% carbon dioxide level, chitin synthesis is ca. 100% greater in the subapical region of P. chrysogenum hyphae than that of the control, in which there was no influent carbon dioxide. Influent carbon dioxide of 10% caused an increase of 200% in chitin synthesis. It is believed that the cell wall must be plasticized before branching can occur and that high amounts of dissolved carbon dioxide cause the cell to lose control of the plasticizing effect, thus the severe morphological changes occur.

• Research Organization: State Univ. of New York, Buffalo (USA)
• OSTI ID: 6922279
• Journal Information: Biotechnol. Bioeng.; (United States), Journal Name: Biotechnol. Bioeng.; (United States) Vol. 32:1; ISSN BIBIA
• Country of Publication: United States
• Language: English

Related Subjects

550801 -- Morphology-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AUTORADIOGRAPHY
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CELL CONSTITUENTS
CELL WALL
CHALCOGENIDES
DRUGS
FUNGI
GROWTH
MORPHOLOGICAL CHANGES
OXIDES
OXYGEN COMPOUNDS
PENICILLIN
PENICILLIUM
PLANTS
TOXICITY