Lung mast cells and hypoxic pulmonary vasoconstriction in cats
Journal Article
·
· Respiration; (United States)
An attempt was made to reduce or eliminate lung mast cells in order to determine the involvement of mast cells in hypoxic pulmonary vasoconstriction. Anesthetized cats were exposed to acute hypoxia (10% O/sub 2/) 20 to 24 h after no pretreatment, after total lung irradiation (3,000 r), after intravenous nitrogen mustard, or after combined lung irradiation and nitrogen mustard. None of the treatments reduced total or perivascular lung mast cell density, or reduced the pulmonary vasoconstrictor response to hypoxia. However, an inverse relationship between lung mast cell density and the pulmonary pressor response to hypoxia was observed. These results suggest that the presence of more lung mast cells may oppose hypoxic pulmonary vasoconstriction.
- Research Organization:
- Univ. of Colorado, Denver
- OSTI ID:
- 6922158
- Journal Information:
- Respiration; (United States), Journal Name: Respiration; (United States) Vol. 35:2; ISSN RESPB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CATS
CONNECTIVE TISSUE CELLS
DRUGS
LUNGS
MAMMALS
MAST CELLS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RESPIRATORY SYSTEM
SOMATIC CELLS
VASOCONSTRICTION
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CATS
CONNECTIVE TISSUE CELLS
DRUGS
LUNGS
MAMMALS
MAST CELLS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RESPIRATORY SYSTEM
SOMATIC CELLS
VASOCONSTRICTION
VERTEBRATES