Airway responses to 2. 0 ppm nitrogen dioxide in normal subjects

Journal Article · Sun May 01 04:00:00 EDT 1988 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1988.9934941· OSTI ID:6922134

Mohsenin, V

Nitrogen dioxide (NO/sub 2/) is a common indoor air pollutant. To characterize the acute respiratory responses to this gas, 18 nonsmoking normal subjects (mean age +/- standard deviation (SD) = 25 +/- 4 yr) were exposed to filtered air or 2 ppm NO/sub 2/ gas for 1 hr in a 30-m3 environmental chamber on different days, typically 1 wk apart, in a double-blind randomized fashion. Lung function tests included forced vital capacity, forced expiratory volume in one second, partial expiratory flow at 40% of vital capacity (Vp40), functional residual capacity, and specific airway conductance, and were measured before and after exposure. Airway reactivity to methacholine inhalation was determined within 45 min of each exposure. The dose of methacholine in mg/ml to cause a 40% decrease in specific airway conductance (PD40) was measured. Airway reactivity to methacholine aerosol increased significantly after NO/sub 2/, which is shown by a decrease in the concentration of methacholine; PD40 (AIR) = 101 +/- 44, PD40 (NO/sub 2/) = 81 +/- 45 mg/ml, p = .003. No significant changes were noted in the lung function tests after NO/sub 2/ exposure. These findings indicate that normal nonsmokers exposed to 2.0 ppm NO/sub 2/ for 1 hr develop an increase in airway reactivity to methacholine aerosol, which is not associated with changes in lung volumes, flow rates, or respiratory symptoms.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT (USA)
• OSTI ID: 6922134
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 43:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BODY
CHALCOGENIDES
CHOLINE
COLLOIDS
DISPERSIONS
DRUGS
EXPOSURE CHAMBERS
HYDROXY COMPOUNDS
INDOOR AIR POLLUTION
LIPOTROPIC FACTORS
LUNGS
MAMMALS
MAN
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
QUATERNARY COMPOUNDS
RESPIRATORY SYSTEM
SENSITIVITY
SOLS
TOXICITY
VERTEBRATES