Airway responses to nitrogen dioxide in asthmatic subjects

Journal Article · Wed Dec 31 23:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531080· OSTI ID:5405306

Mohsenin, V

Nitrogen dioxide is a common indoor air pollutant. In order to characterize the respiratory responses to this gas, 10 asthmatics (mean age +/- SD = 30 +/- 8 yrs) were exposed to air and 0.5 ppm NO/sub 2/ gas for 1 h in a 30-m3 environmental chamber on different days in a double-blind randomized fashion. The forced vital capacity, (VC), functional residual capacity, forced expiratory volume in 1 s, partial expiratory flow at 40% VC (Vp 40), and specific airway conductance were measured before and after exposure. Airway reactivity to methacholine inhalation was determined after each exposure. The dose of methacholine in milligrams per milliliter to cause a 40% decrease in Vp 40 was measured. None of the subjects reported any significant symptoms after exposure. Significant potentiation of airway reactivity was noted after NO/sub 2/ exposure in asthmatic subjects as a group (PD40(AIR) = 9.2 +/- SD 15.0 versus PD40(NO/sub 2/) = 4.6 +/- SD 8.2 mg/ml, p = 0.042). No significant changes were noted in other lung functions after NO/sub 2/ exposure. These findings indicate that asthmatics exposed to 0.5 ppm NO/sub 2/ develop heightened airway reactivity.

• Research Organization: John B. Pierce Foundation Laboratory, New Haven, CT
• OSTI ID: 5405306
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 22:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ASTHMA
BODY
CHALCOGENIDES
CHOLINE
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EXPOSURE CHAMBERS
HYDROXY COMPOUNDS
INDOOR AIR POLLUTION
INHALATION
INTAKE
LIPOTROPIC FACTORS
LUNGS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
QUATERNARY COMPOUNDS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
TOXICITY