Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities

Journal Article · Thu Mar 01 04:00:00 EST 1990 · Journal of Experimental Medicine; (USA)

DOI:https://doi.org/10.1084/jem.171.3.935· OSTI ID:6919654

Roberts, J L; Sharrow, S O; Singer, A ^[1]

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1. National Cancer Institute, National Institutes of Health, Bethesda, MD (USA)

The present study demonstrates that immune tolerance can be achieved in the thymus both by clonal deletion and by clonal inactivation, but that the two tolerant states are induced by cellular elements with different radiation sensitivities. TCR engagement of self antigens on bone marrow-derived, radiation-sensitive (presumably dendritic) cells induces clonal deletion of developing thymocytes, whereas TCR engagement of self antigens on radiation-resistant cellular elements, such as thymic epithelium, induces clonal anergy. The nondeleted, anergic thymocytes can express IL-2-Rs but are unable to proliferate in response to either specific antigen or anti-TCR antibodies, and do develop into phenotypically mature cells that emigrate out of the thymus and into the periphery.

• OSTI ID: 6919654
• Journal Information: Journal of Experimental Medicine; (USA), Journal Name: Journal of Experimental Medicine; (USA) Vol. 171:3; ISSN 0022-1007; ISSN JEMEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CULTURES
CLONE CELLS
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NERVE CELLS
ORGANS
PHENOTYPE
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
THYMUS
THYMUS CELLS
VERTEBRATES