Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Comparison of age-related changes in in vivo and in vitro measures of testicular steroidogenesis after acute cadmium exposure in the sprague-dawley rat

Technical Report ·
OSTI ID:6919038
;

Previous reports have demonstrated that cadmium- induced testicular necrosis is an age-dependent process. However, little information exists on age-related intestitial cell (IC) damage in the rat after acute exposure to Cd. In-vitro and in-vivo measures of testicular damage were utilized to compare the sensitivity of these measures and to further investigate age-related Cd-induced testicular damage. Testes, epididymides, and seminal-vesicle weights, serum testosterone (sT), hCG-stimulated sT, and basal and stimulated IC testosterone (T) production were compared in rats 21 d following an injection of 2 mg Cd/kg at 9, 37, 67, and 97 d of age. The only Cd-related change noted for immature rats was an 84% reduction in sT. In rats injected when 37 d old, hCG-stimulated sT and epididymides and seminal-vesicle weights, although depressed, were not significantly altered. However, all other measurements were significantly depressed. All measures of testicular damage were significantly depressed in rats injected at 67 and 97 d of age. Overall, in vitro measures were more sensitive indicators of Cd-induced testicular damage than in vivo measures.

Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
OSTI ID:
6919038
Report Number(s):
PB-90-185257/XAB; EPA--600/J-89/282
Country of Publication:
United States
Language:
English

Similar Records

Comparison of age-related changes in in vivo and in vitro measures of testicular steroidogenesis after acute cadmium exposure in the sprague-dawley rat
Journal Article · Sat Dec 31 23:00:00 EST 1988 · Journal of Toxicology and Environmental Health; (USA) · OSTI ID:5029976
Age-related dose response of selected reproductive parameters to acute cadmium chloride exposure in the male Long-Evans rat
Journal Article · Tue Dec 31 23:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States) · OSTI ID:6636435
Assessment of the male reproductive system in the preweaning rat following Mn/sub 3/O/sub 4/ exposure
Journal Article · Mon Dec 31 23:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States) · OSTI ID:5434246

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AGE DEPENDENCE
ANDROGENS
ANDROSTANES
ANIMALS
BODY
CADMIUM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GONADS
HORMONES
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
KETONES
MALE GENITALS
MAMMALS
METALS
NECROSIS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RODENTS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TOXICITY
VERTEBRATES