Enhanced tumorigenicity of cloned UV-regressor tumor lines following selected in vivo and in vitro manipulations

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Am. J. Pathol.; (United States)

OSTI ID:6915289

Schmitt, M K; Roberts, L K; Gahring, L C; Daynes, R A

Passage of cloned ultraviolet (UV) radiation-induced fibrosarcomas with regressor phenotype through 500-rad-irradiated syngeneic mice resulted in their conversion to transplantable progressor tumors. A similar conversion in tumorigenic phenotype (regressor leads to progressor) was found to be inducible in vitro by coculturing a cloned regressor tumor with normal splenocytes, but not with splenocytes from tumor-immune or UV-irradiated animals. Recloning of regressor and converted progressor tumor lines yielded regressor and progressor phenotype subclones, respectively, suggesting a degree of stability in their growth phenotype. Although all of the cloned progressor tumors tested were found to be cross-reactive with related regressor tumor lines, suggesting that related clones share a similar tumor-specific transplantation antigen, the progressor clones appeared to be less immunogenic than the regressor clones. Potential mechanisms that influence this conversion in tumorigenic phenotype are discussed.

• Research Organization: Univ. of Utah Medical Center, Salt Lake City
• OSTI ID: 6915289
• Journal Information: Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 113:3; ISSN AJPAA
• Country of Publication: United States
• Language: English

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