Removal of atrial natriuretic peptide by perfused rabbit lungs in situ
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Removal of iodinated 28-amino acid atrial natriuretic peptide ((/sup 125/I)ANP) by rabbit lungs was measured by indicator-dilution methods. After bolus injection of 6.5 pmoles of (/sup 125/I)ANP, 66.9 +/- 2.9% was removed in a single pass through the lungs. Removal was unaltered by a kininase II inhibitor but was reversibly decreased by unlabelled ANP. Thus the lungs can remove ANP from the pulmonary circulation by a mechanism that does not involve hydrolysis by kininase II. Lungs therefore may be involved in regulating systemic concentrations and hence renal and other actions of ANP.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 6915104
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Removal of atrial natriuretic factor by perfused rabbit lungs in situ
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Tue Mar 04 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:6965917
Atrial natriuretic polypeptide-like material in rat lung
Conference
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Tue Mar 04 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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OSTI ID:7189439
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Fri May 01 00:00:00 EDT 1987
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
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OSTI ID:6071495
Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BODY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
RABBITS
RADIOISOTOPES
REMOVAL
RESPIRATORY SYSTEM
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BODY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
RABBITS
RADIOISOTOPES
REMOVAL
RESPIRATORY SYSTEM
TRACER TECHNIQUES
VERTEBRATES