Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma

Journal Article · · Arch. Ophthalmol. (Chicago); (United States)
; ;
A 31-year-old woman had bilateral retinoblastoma diagnosed in early childhood. The right eye was enucleated at the age of 1 year, and the left eye was treated with radiation therapy (a total dose of 16,000 rad). Twenty-three years later, in 1975, a subcutaneous mass was noted in the left periorbital region. A biopsy specimen of the mass was taken and a diagnosis of pleomorphic postradiation sarcoma was made. Electron microscopic studies of the periorbital mass confirmed the diagnosis of leiomyosarcoma. After additional radiation therapy, the residual mass was surgically excised. Five years later, a right renal mass, which histologically proved to be a renal cell carcinoma, was discovered. She was treated with nephrectomy, radiation, and chemotherapy. A recent follow-up examination disclosed that the patient is alive and apparently without any evidence of metastatic disease, 30 years after the diagnosis of bilateral retinoblastoma was made. The literature is reviewed regarding postradiation sarcomas and the occurrence of second malignant neoplasms in patients with retinoblastoma.
OSTI ID:
6915076
Journal Information:
Arch. Ophthalmol. (Chicago); (United States), Journal Name: Arch. Ophthalmol. (Chicago); (United States) Vol. 101:10; ISSN AROPA
Country of Publication:
United States
Language:
English

Similar Records

Orbital leiomyosarcoma after radiation therapy for bilateral retinoblastoma
Journal Article · Sat Oct 01 00:00:00 EDT 1983 · Arch. Ophthalmol. (Chicago); (United States) · OSTI ID:7133378
SARCOMA FOLLOWING IRRADIATED RETINOBLASTOMA: REPORT OF A CASE
Journal Article · Tue Oct 01 00:00:00 EDT 1963 · Arch. Ophthalmol. · OSTI ID:4094922
Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome
Journal Article · Tue Sep 15 00:00:00 EDT 1987 · Cancer (Philadelphia); (United States) · OSTI ID:6069156

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
DISEASES
ETIOLOGY
EYES
FACE
HEAD
LATENCY PERIOD
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RETINA
SARCOMAS
SENSE ORGANS
SIDE EFFECTS
THERAPY