Effects of air pollutants on the oxidative metabolism and phagocytic capacity of pulmonary alveolar macrophages
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Isolated rabbit pulmonary alveolar macrophages were found to be a convenient biological model system, relevant for studies of the toxicity of air pollutants. The phagocytic capacity and the oxygen consumption were used as test parameters and studied simultaneously on the same cells. The toxicity of extracts of airborne particles (phi < 15 ..mu..m) collected in urban and rural areas was investigated and compared to a cigarette-smoke condensate. An extract of particles from a car tunnel was found to be the most toxic air sample, inhibiting phagocytosis as well as respiration of the macrophages at a concentration representing 5 m/sup 3/ air/ml cell suspension. A corresponding sample collected on a roof of a five-storied building in the central area of a city (population 600,000) was found to inhibit phagocytosis but did not affect respiration. Further investigations revealed that one effect of the tunnel extract could be explained as an uncoupling of the mitochondrial respiratory control. Compared to the cigarette-smoke condensate, the toxicity of the air samples was infinitesimal.
- Research Organization:
- Univ. of Stockholm, Sweden
- OSTI ID:
- 6914243
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:2-3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
AIR SAMPLERS
ANIMAL CELLS
ANIMALS
AUTOMOBILES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
EQUIPMENT
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
INHALATION
INHIBITION
INTAKE
MACROPHAGES
MAMMALS
PARTICLE SIZE
PARTICLES
PARTICULATES
PHAGOCYTES
PHAGOCYTOSIS
POLLUTION
RABBITS
RESIDUES
RESPIRATION
RURAL AREAS
SAMPLERS
SIZE
SMOKES
SOLS
SOMATIC CELLS
TOBACCO SMOKES
TUNNELS
UNDERGROUND FACILITIES
URBAN AREAS
VEHICLES
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
AIR SAMPLERS
ANIMAL CELLS
ANIMALS
AUTOMOBILES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
EQUIPMENT
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
INHALATION
INHIBITION
INTAKE
MACROPHAGES
MAMMALS
PARTICLE SIZE
PARTICLES
PARTICULATES
PHAGOCYTES
PHAGOCYTOSIS
POLLUTION
RABBITS
RESIDUES
RESPIRATION
RURAL AREAS
SAMPLERS
SIZE
SMOKES
SOLS
SOMATIC CELLS
TOBACCO SMOKES
TUNNELS
UNDERGROUND FACILITIES
URBAN AREAS
VEHICLES
VERTEBRATES
WASTES