INEL BNCT Research Program, March/April 1992

Technical Report · Tue Sep 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/6913582· OSTI ID:6913582

Venhuizen, J R

This report presents summaries for two months of current research for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murino screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronopheoylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

• Research Organization: EG and G Idaho, Inc., Idaho Falls, ID (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6913582
• Report Number(s): EGG-BNCT-10016-03/04; ON: DE93001931
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
AMINO ACIDS
BODY
BORON COMPOUNDS
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DISEASES
DOCUMENT TYPES
DRUGS
HORMONES
LABELLED COMPOUNDS
LIPOSOMES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHENYLALANINE
PITUITARY HORMONES
PROGRESS REPORT
PROTEINS
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RBE
STH
THERAPY