INEL BNCT research program, July--August 1992

Technical Report · Thu Oct 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/10112755· OSTI ID:10112755

Venhuizen, J R

This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

• Research Organization: EG and G Idaho, Inc., Idaho Falls, ID (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 10112755
• Report Number(s): EGG-BNCT--10016; ON: DE93005236
• Country of Publication: United States
• Language: English

Related Subjects

550603
62 RADIOLOGY AND NUCLEAR MEDICINE
EXTERNAL RADIATION IN THERAPY
LIPOPROTEINS
LIPOSOMES
NEUTRON THERAPY
ORGANIC BORON COMPOUNDS
PHENYLALANINE
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
TOXICITY