Validation of techniques for the destruction of dimethyl sulfate

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668591394518· OSTI ID:6909363

Lunn, G; Sansone, E B

It has been reported that dimethyl sulfate (DMS) can be degraded with sodium hydroxide solution (1 mol/L), sodium carbonate solution (1 mol/L), or ammonium hydroxide solution (1.5 mol/L). This has now been confirmed. Complete destruction of undiluted DMS or DMS in solvents miscible with water (methanol, ethanol, DMSO, DMF, acetone) or solvents partially miscible or immiscible with water (toluene, p-xylene, benzene, 1-pentanol, ethyl acetate, chloroform, carbon tetrachloride, acetonitrile) could be obtained using any of the above methods. Reaction times were 15 min after homogeneity was obtained for undiluted DMS, 15 min for solutions in methanol, ethanol, DMSO, and DMF, one hour for solutions in acetone, three hours for acetonitrile, and one day for the other solvents listed above. The final reaction mixtures were tested for mutagenicity, and when the solutions were not cytotoxic, no mutagenic response was obtained. DMS in solution was determined by a colorimetric method. The products of the reactions were found to be methanol when NaOH and Na/sub 2/ CO/sub 3/ were used and methylamine, dimethylamine, trimethylamine, and methanol when ammonium hydroxide was used. The stability of DMS in various solvents was also determined.

• Research Organization: Program Resources Inc., Frederick, MD
• OSTI ID: 6909363
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Journal Issue: 3 Vol. 46:3; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
570000 -- Health & Safety
99 GENERAL AND MISCELLANEOUS
ALKALI METAL COMPOUNDS
ALKANES
AMMONIUM COMPOUNDS
AMMONIUM HYDROXIDES
CARBON COMPOUNDS
CARBONATES
CHEMICAL REACTION KINETICS
CHEMICAL REACTIONS
DATA
DECOMPOSITION
EXPERIMENTAL DATA
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXIDES
INFORMATION
KINETICS
METHANE
NUMERICAL DATA
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
REACTION KINETICS
SODIUM CARBONATES
SODIUM COMPOUNDS
SODIUM HYDROXIDES
SULFATES
SULFUR COMPOUNDS