Preparation of C-11 labeled dimethylsulfoxide (DMSO)

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6793954

Meyer, J; Osterholz, A; Pretschner, P; Hundeshagan, H

Dimethylsulfoxide (DMSO) is used as a carrier for percutanous resorption of various pharmaceuticals. Besides the evaluation of its carrier characteristics, C-11 labeled DMSO may allow the determination of peripheral blood flow by measurement of the kinetics of DMSO skin penetration, its disappearance at the site of application and its appearance in blood. Routinely produced n.c.a. (C-11)-methyliodide (ca. 20 GBq(540 mCi)) is collected in 100 ..mu..l acetone. The precursor is mixed with 10 ..mu..Mol sodium-sulfide in 100 ..mu..l water and reacted for 5 min. at 60/sup 0/C. Thereafter 20 ..mu..Mol methyliodide carrier in 50 ..mu..l acetone are added and the reaction is continued for 5 min. The rection generates highly volatile dimethylsulfide which is carried with a stream of nitrogen into a small vessel containing 100 ..mu..Mol hydrogenperoxide in 200 ..mu..l acetone. The oxydation to DMSO proceeds at room temperature and is complete within additional 5 min. The acetone is then evaporated and the aqueous residue is purified by loading it onto a C-18 reversed phase cartridge and elution with 10 ml of physiol. NaCl solution.

• Research Organization: Medizinische Hochschule Hannover
• OSTI ID: 6793954
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700 -- Radiochemistry & Nuclear Chemistry
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ACETONE
ACTIVATION ENERGY
ALKALI METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BINDING ENERGY
BLOOD FLOW
CARBON 11
CARBON ISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
DIAGNOSTIC USES
DILUTION
DMSO
DRUGS
ENERGY
EVEN-ODD NUCLEI
GAS CHROMATOGRAPHY
HALIDES
HALOGEN COMPOUNDS
IODIDES
IODINE COMPOUNDS
ISOTOPES
KETONES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PRODUCTION
PURIFICATION
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SIMULATION
SKIN ABSORPTION
SODIUM CHLORIDES
SODIUM COMPOUNDS
SULFOXIDES
SYNTHESIS
UPTAKE
USES
YIELDS