Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986

Technical Report · Fri Dec 01 04:00:00 EST 1989

OSTI ID:6905599

Morgan, E W; Frost, D F; Wheller, C R; Korte, D W

The acute oral toxicity of JA-2 Solid Propellant was determined in male and female ICR mice by using an oral gavage, split-dose method. The MLD was 3774.6 + or - 150.5 mg/kg for male mice and 3528.8 + or - 133.8 mg/kg for female mice. JA-2 produced component, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors, inactivity, depression of reflexes, loss of equilibrium, opisthotonus, and increased respiratory activity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included perianal staining, hunched posture, squinting, and rough coat. Most animals exhibited signs by 2 hours after dosing and either had died or the signs had cleared within 5 days of dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.

• Research Organization: Letterman Army Inst. of Research, San Francisco, CA (USA)
• OSTI ID: 6905599
• Report Number(s): AD-A-217264/1/XAB; LAIR--414
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CHEMICAL EXPLOSIVES
ESTERS
EXPLOSIVES
MAMMALS
MICE
NITRATES
NITRIC ACID ESTERS
NITROGEN COMPOUNDS
NITROGLYCERIN
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PROPELLANTS
RESPIRATORY SYSTEM
RODENTS
SYMPTOMS
TOXICITY
VERTEBRATES