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Title: Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986

Abstract

The acute oral toxicity of JA-2 Solid Propellant was determined in male and female ICR mice by using an oral gavage, split-dose method. The MLD was 3774.6 + or - 150.5 mg/kg for male mice and 3528.8 + or - 133.8 mg/kg for female mice. JA-2 produced component, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors, inactivity, depression of reflexes, loss of equilibrium, opisthotonus, and increased respiratory activity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included perianal staining, hunched posture, squinting, and rough coat. Most animals exhibited signs by 2 hours after dosing and either had died or the signs had cleared within 5 days of dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.

Authors:
; ; ;
Publication Date:
Research Org.:
Letterman Army Inst. of Research, San Francisco, CA (USA)
OSTI Identifier:
6905599
Report Number(s):
AD-A-217264/1/XAB; LAIR--414
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NITRATES; TOXICITY; NITROGLYCERIN; PROPELLANTS; MICE; ORAL ADMINISTRATION; RESPIRATORY SYSTEM; SYMPTOMS; ANIMALS; CHEMICAL EXPLOSIVES; ESTERS; EXPLOSIVES; MAMMALS; NITRIC ACID ESTERS; NITROGEN COMPOUNDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RODENTS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Morgan, E.W., Frost, D.F., Wheller, C.R., and Korte, D.W. Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986. United States: N. p., 1989. Web.
Morgan, E.W., Frost, D.F., Wheller, C.R., & Korte, D.W. Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986. United States.
Morgan, E.W., Frost, D.F., Wheller, C.R., and Korte, D.W. 1989. "Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986". United States. doi:.
@article{osti_6905599,
title = {Acute oral toxicity of JA-2 solid propellant in icr mice. Report for 17 December 1985-17 January 1986},
author = {Morgan, E.W. and Frost, D.F. and Wheller, C.R. and Korte, D.W.},
abstractNote = {The acute oral toxicity of JA-2 Solid Propellant was determined in male and female ICR mice by using an oral gavage, split-dose method. The MLD was 3774.6 + or - 150.5 mg/kg for male mice and 3528.8 + or - 133.8 mg/kg for female mice. JA-2 produced component, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors, inactivity, depression of reflexes, loss of equilibrium, opisthotonus, and increased respiratory activity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included perianal staining, hunched posture, squinting, and rough coat. Most animals exhibited signs by 2 hours after dosing and either had died or the signs had cleared within 5 days of dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1989,
month =
}

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