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Title: Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985

Abstract

The acute oral toxicity of JA-2 Solid Propellant was determined in male and female Sprague-Dawley rats by using an oral gavage split-dose method. The MLD was 3990.6 + or - 349.7 mg/kg for male rats and 2545.9 + or - 421.1 mg/kg for female rats. JA-2 produced clinical signs that were attributed to its nitrate ester components, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors and twitching, cyanosis, and increases in respiratory rate and depth. Other clinical signs observed were associated with the general malaise of the animals following dosing and included hunched posture, rough coat, reddish stains around the eyes and nose, and perianal staining. Most animals exhibited signs by 4 hours after dosing and either had died or the signs had cleared by 96 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.

Authors:
; ; ;
Publication Date:
Research Org.:
Letterman Army Inst. of Research, San Francisco, CA (USA)
OSTI Identifier:
6905588
Report Number(s):
AD-A-217347/4/XAB; LAIR--412
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NITRATES; TOXICITY; NITROGLYCERIN; PROPELLANTS; ORAL ADMINISTRATION; RATS; RESPIRATION; SYMPTOMS; ANIMALS; CHEMICAL EXPLOSIVES; ESTERS; EXPLOSIVES; MAMMALS; NITRIC ACID ESTERS; NITROGEN COMPOUNDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RODENTS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Brown, L.D., Justus, J.D., Wheeler, C.R., and Korte, D.W. Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985. United States: N. p., 1989. Web.
Brown, L.D., Justus, J.D., Wheeler, C.R., & Korte, D.W. Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985. United States.
Brown, L.D., Justus, J.D., Wheeler, C.R., and Korte, D.W. 1989. "Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985". United States. doi:.
@article{osti_6905588,
title = {Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985},
author = {Brown, L.D. and Justus, J.D. and Wheeler, C.R. and Korte, D.W.},
abstractNote = {The acute oral toxicity of JA-2 Solid Propellant was determined in male and female Sprague-Dawley rats by using an oral gavage split-dose method. The MLD was 3990.6 + or - 349.7 mg/kg for male rats and 2545.9 + or - 421.1 mg/kg for female rats. JA-2 produced clinical signs that were attributed to its nitrate ester components, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors and twitching, cyanosis, and increases in respiratory rate and depth. Other clinical signs observed were associated with the general malaise of the animals following dosing and included hunched posture, rough coat, reddish stains around the eyes and nose, and perianal staining. Most animals exhibited signs by 4 hours after dosing and either had died or the signs had cleared by 96 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1989,
month =
}

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