Acute oral toxicity of ja-2 solid propellant in sprague-dawley rats. Report for 12 November-19 December 1985

Technical Report · Fri Dec 01 04:00:00 EST 1989

OSTI ID:6905588

Brown, L D; Justus, J D; Wheeler, C R; Korte, D W

The acute oral toxicity of JA-2 Solid Propellant was determined in male and female Sprague-Dawley rats by using an oral gavage split-dose method. The MLD was 3990.6 + or - 349.7 mg/kg for male rats and 2545.9 + or - 421.1 mg/kg for female rats. JA-2 produced clinical signs that were attributed to its nitrate ester components, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors and twitching, cyanosis, and increases in respiratory rate and depth. Other clinical signs observed were associated with the general malaise of the animals following dosing and included hunched posture, rough coat, reddish stains around the eyes and nose, and perianal staining. Most animals exhibited signs by 4 hours after dosing and either had died or the signs had cleared by 96 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class.

• Research Organization: Letterman Army Inst. of Research, San Francisco, CA (USA)
• OSTI ID: 6905588
• Report Number(s): AD-A-217347/4/XAB; LAIR--412
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CHEMICAL EXPLOSIVES
ESTERS
EXPLOSIVES
MAMMALS
NITRATES
NITRIC ACID ESTERS
NITROGEN COMPOUNDS
NITROGLYCERIN
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PROPELLANTS
RATS
RESPIRATION
RODENTS
SYMPTOMS
TOXICITY
VERTEBRATES