Nonidentity of Lyt phenotypes and radiosensitivity of ''early'' and ''late'' mif producers responding to h-2 antigens
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The aim of this investigation was to compare Lyt markers and some properties of ''early'' and ''late'' macrophage migration inhibition factor (MIF) producers specific for H-2 antigens. BALB/c mice were immunized by injection of spleen cells of C57BL/6 mice, irradiated in a dose of 20 Gy (/sup 137/Cs, 7.4 Gy/min). Immune lymphocytes were irradiated on a /sup 137/Cs apparatus in doses of 500, 1500, and 3000 rads. To study subpopulations of MIF producers cells formed in the course of secondary allogeneic stimulation were investigated. The study of radioresistance of the MIF producers showed that ''early'' and ''late'' MIF producers differ in their sensitivity to gamma-irradiation.
- Research Organization:
- M.M. Shemyakin Institute of Biorganic Chemistry, Oncologic Sci. Ctr., Moscow
- OSTI ID:
- 6905408
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 99:2; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GROWTH FACTORS
IMMUNE REACTIONS
IMMUNE SERUMS
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MACROPHAGES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MICE
MIGRATION
MITOGENS
MONOCLONAL ANTIBODIES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GROWTH FACTORS
IMMUNE REACTIONS
IMMUNE SERUMS
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MACROPHAGES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MICE
MIGRATION
MITOGENS
MONOCLONAL ANTIBODIES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES