Cadmium-induced acute lung injury: compounds repair response following thyroidectoym

Journal Article · Sun Dec 01 04:00:00 EST 1985 · Environ. Res.; (United States)

OSTI ID:6904694

Palmer, K C; Mari, F; Malian, M S

The role of thyroid hormone in the pulmonary repair process following cadmium chloride-induced acute injury, was assessed in the present study. Thyroidectomized (Thyx), male Sprague-Dawley rats were exposed by inhalation to cadmium chloride aerosol (CdCl/sub 2/, 10 mg/m/sup 3/). Rats were sacrificed 1 hr after (/sup 3/H)thymicine (/sup 3/H-T) injection at intervals up to 10 days after exposure. Thyroidectomy, followed by CdCl/sub 2/, produced earlier and more severe acute injury in the form of alveolar hemorrhage edema and hyaline membrane formation, than CdCl/sub 2/alone. However, Type 2 cell hyperplasia was markedly reduced in this group of rats compared with CdCl/sub 2/ controls. Uptake of /sup 3/H-T by Thyx-CdCl/sub 2/ lung tissue was only 40% of that measured in CdCl/sub 2/ controls. Autoradiographic studies indicated that Type 2 cell labeling was less than 66% of controls up to 3 days after exposure. Cells obtained by lung lavage of Thyx-CdCl/sub 2/ rats were reduced in number up to 60% with respect to controls, during the first week after exposure. Additionally, the activities of lung antioxidant enzymes (glucose-6-phosphate dehydrogenase, superoxide dismutase, and glutathione peroxidase were significantly inhibited (45-55%) throughout the experiment in Thyx-CdCl/sub 2/ animals compared with normal rats.

• Research Organization: Wayne State Univ., Detroit, MI
• OSTI ID: 6904694
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 38:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL FUNCTIONS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
FUNCTIONS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HORMONES
INHALATION
INHIBITION
INJURIES
INTAKE
LABELLED COMPOUNDS
LUNGS
MAMMALS
METALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDE HORMONES
PYRIMIDINES
RATS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
THYMIDINE
THYROID HORMONES
TOXICITY
TRITIUM COMPOUNDS
VERTEBRATES