Benzoyl peroxide interferes with metabolic co-operation between cultured human epidermal keratinocytes

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Carcinogenesis (N.Y.); (United States)

OSTI ID:6903830

Lawrence, N J; Parkinson, E K; Emmerson, A

The ability of benzoyl peroxide to inhibit metabolic co-operation in rodent cell cultures may be relevant to its recently reported tumour promoting activity in mouse epidermis. We show here that non-toxic doses of this compound reduce metabolic co-operation between human epidermal keratinocytes to approximately 30% of that found in controls. The doses of benzoyl peroxide used did not affect keratinocyte morphology or their rate of attachment to the culture substratum. These results could be important as benzoyl peroxide is widely used in industry.

• Research Organization: Department of Cancer Studies, The Medical School, University of Birmingham, UK
• OSTI ID: 6903830
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:3; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BENZOYL PEROXIDE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CELL CULTURES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXYGEN COMPOUNDS
PATHOGENESIS
PEROXIDES
RATS
RODENTS
VERTEBRATES